/* OncoGx Biology & Variant Interpreter: styles (from the standalone build).
   Site theme overrides are at the end of this file. */
.oncogx-biology {
  --ogb-navy: #0B2545;
  --ogb-navy-2: #13315C;
  --ogb-teal: #14B8A6;
  --ogb-teal-ink: #0F766E;
  --ogb-bg: #F3F6F9;
  --ogb-surface: #FFFFFF;
  --ogb-surface-2: #EDF1F5;
  --ogb-surface-3: #E2E8EF;
  --ogb-line: #D5DDE6;
  --ogb-line-strong: #B9C5D2;
  --ogb-ink: #0E1A2B;
  --ogb-ink-2: #3D4B5E;
  --ogb-muted: #5D6B7E;
  --ogb-gene: #4338CA;      --ogb-gene-bg: #EEF0FF;
  --ogb-variant: #0369A1;   --ogb-variant-bg: #E6F4FB;
  --ogb-protein: #7E22CE;   --ogb-protein-bg: #F5EDFE;
  --ogb-pathway: #047857;   --ogb-pathway-bg: #E6F6EF;
  --ogb-interact: #B45309;  --ogb-interact-bg: #FDF2E3;
  --ogb-danger: #BE123C;    --ogb-danger-bg: #FDECEF;
  --ogb-warn: #A16207;      --ogb-warn-bg: #FEF6DC;
  --ogb-ok: #047857;        --ogb-ok-bg: #E6F6EF;
  --ogb-focus: #14B8A6;
  --ogb-radius-lg: 14px;
  --ogb-radius: 10px;
  --ogb-radius-sm: 6px;
  --ogb-shadow: 0 1px 2px rgba(11,37,69,.06), 0 4px 16px rgba(11,37,69,.06);
  --ogb-font: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif;
  --ogb-mono: ui-monospace, SFMono-Regular, "SF Mono", Menlo, Consolas, "Liberation Mono", monospace;
  --ogb-maxw: 1320px;
  --ogb-sticky-top: 0px;

  display: block;
  color: var(--ogb-ink);
  background: var(--ogb-bg);
  font-family: var(--ogb-font);
  font-size: 16px;
  line-height: 1.55;
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
  padding-bottom: env(safe-area-inset-bottom, 0px);
}
.oncogx-biology[data-theme="dark"] {
  --ogb-bg: #0A1422; --ogb-surface: #0F1D30; --ogb-surface-2: #14263D; --ogb-surface-3: #1B304B;
  --ogb-line: #22395A; --ogb-line-strong: #33507A; --ogb-ink: #E6EDF6; --ogb-ink-2: #BAC7D8; --ogb-muted: #93A3B8;
  --ogb-teal-ink: #5EEAD4;
  --ogb-gene: #A5B4FC; --ogb-gene-bg: #1E2350; --ogb-variant: #7DD3FC; --ogb-variant-bg: #0B3048;
  --ogb-protein: #D8B4FE; --ogb-protein-bg: #2E1845; --ogb-pathway: #6EE7B7; --ogb-pathway-bg: #0B3328;
  --ogb-interact: #FCD34D; --ogb-interact-bg: #3A2A0B; --ogb-danger: #FDA4AF; --ogb-danger-bg: #401520;
  --ogb-warn: #FCD34D; --ogb-warn-bg: #3A2E0B; --ogb-ok: #6EE7B7; --ogb-ok-bg: #0B3328;
  --ogb-shadow: 0 1px 2px rgba(0,0,0,.3), 0 6px 20px rgba(0,0,0,.25);
}
@media (prefers-color-scheme: dark) {
  .oncogx-biology[data-theme="auto"] {
    --ogb-bg: #0A1422; --ogb-surface: #0F1D30; --ogb-surface-2: #14263D; --ogb-surface-3: #1B304B;
    --ogb-line: #22395A; --ogb-line-strong: #33507A; --ogb-ink: #E6EDF6; --ogb-ink-2: #BAC7D8; --ogb-muted: #93A3B8;
    --ogb-teal-ink: #5EEAD4;
    --ogb-gene: #A5B4FC; --ogb-gene-bg: #1E2350; --ogb-variant: #7DD3FC; --ogb-variant-bg: #0B3048;
    --ogb-protein: #D8B4FE; --ogb-protein-bg: #2E1845; --ogb-pathway: #6EE7B7; --ogb-pathway-bg: #0B3328;
    --ogb-interact: #FCD34D; --ogb-interact-bg: #3A2A0B; --ogb-danger: #FDA4AF; --ogb-danger-bg: #401520;
    --ogb-warn: #FCD34D; --ogb-warn-bg: #3A2E0B; --ogb-ok: #6EE7B7; --ogb-ok-bg: #0B3328;
    --ogb-shadow: 0 1px 2px rgba(0,0,0,.3), 0 6px 20px rgba(0,0,0,.25);
  }
}
.oncogx-biology *, .oncogx-biology *::before, .oncogx-biology *::after { box-sizing: border-box; }
.oncogx-biology [hidden] { display: none !important; }
:where(.oncogx-biology) a { color: var(--ogb-teal-ink); text-underline-offset: 2px; }
:where(.oncogx-biology) a:hover { text-decoration-thickness: 2px; }
.oncogx-biology .ogb-ext { width: 13px; height: 13px; vertical-align: -2px; margin-left: 3px; flex: none; display: inline-block; }
.oncogx-biology :focus-visible { outline: 3px solid var(--ogb-focus); outline-offset: 2px; border-radius: 4px; }
:where(.oncogx-biology) :where(button, input, select, textarea) { font: inherit; color: inherit; }
:where(.oncogx-biology) :where(h1, h2, h3, h4) { margin: 0; line-height: 1.2; letter-spacing: -0.01em; }
:where(.oncogx-biology) p { margin: 0 0 .75em; }
:where(.oncogx-biology) p:last-child { margin-bottom: 0; }
.oncogx-biology code, .oncogx-biology .ogb-mono { font-family: var(--ogb-mono); font-size: .9em; overflow-wrap: anywhere; }
.oncogx-biology .ogb-sr { position: absolute !important; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0; }
.oncogx-biology .ogb-skip { position: absolute; left: 12px; top: -60px; z-index: 50; background: var(--ogb-navy); color: #fff; padding: 8px 14px; border-radius: 8px; text-decoration: none; }
.oncogx-biology .ogb-skip:focus { top: 12px; }
.ogb-wrap { max-width: var(--ogb-maxw); margin: 0 auto; padding: 0 clamp(14px, 3vw, 28px); }

/* ── Header ─────────────────────────────────────────────── */
.ogb-header { background: var(--ogb-navy); color: #fff; padding: 22px 0 76px; position: relative; overflow: hidden; }
.ogb-header::after { /* a faint sequence track: the one decorative element */
  content: ""; position: absolute; left: 0; right: 0; bottom: 30px; height: 2px;
  background: repeating-linear-gradient(90deg, rgba(20,184,166,.55) 0 18px, transparent 18px 22px, rgba(255,255,255,.18) 22px 30px, transparent 30px 34px);
  opacity: .7;
}
.ogb-header-top { display: flex; align-items: center; justify-content: space-between; gap: 16px; flex-wrap: wrap; }
.ogb-logo { display: inline-flex; align-items: center; gap: 10px; color: #fff; text-decoration: none; font-weight: 700; font-size: 1.05rem; letter-spacing: .01em; }
.ogb-logo-slot img { max-height: 34px; width: auto; display: block; }
.ogb-logo svg { width: 30px; height: 30px; }
.ogb-header-badges { display: flex; gap: 8px; flex-wrap: wrap; }
.ogb-hbadge { display: inline-flex; align-items: center; gap: 7px; padding: 6px 12px; border-radius: 999px; font-size: .82rem; line-height: 1.3;
  background: rgba(255,255,255,.08); color: #E3F6F3; border: 1px solid rgba(255,255,255,.18); cursor: pointer; text-align: left; }
.ogb-hbadge:hover { background: rgba(255,255,255,.14); }
.ogb-hbadge svg { width: 15px; height: 15px; flex: none; color: var(--ogb-teal); }
.ogb-title { margin-top: 26px; max-width: 920px; }
.ogb-title h1 { font-size: clamp(1.7rem, 3.4vw, 2.5rem); font-weight: 750; letter-spacing: -0.022em; color: #fff; }
.ogb-title p { margin-top: 8px; color: #BFD3E6; font-size: clamp(.98rem, 1.4vw, 1.1rem); max-width: 62ch; }

/* ── Search ─────────────────────────────────────────────── */
.ogb-searchcard { position: relative; margin-top: -54px; background: var(--ogb-surface); border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius-lg); box-shadow: var(--ogb-shadow); padding: clamp(16px, 2.4vw, 24px); }
.ogb-searchrow { display: flex; gap: 10px; align-items: stretch; }
.ogb-searchfield { position: relative; flex: 1; min-width: 0; }
.ogb-searchfield svg { position: absolute; left: 16px; top: 50%; transform: translateY(-50%); width: 20px; height: 20px; color: var(--ogb-muted); pointer-events: none; }
.ogb-input-lg { width: 100%; height: 56px; padding: 0 44px 0 48px; border-radius: 12px; border: 1.5px solid var(--ogb-line-strong); background: var(--ogb-surface); font-size: 1.08rem; }
.ogb-input-lg::placeholder { color: var(--ogb-muted); }
.ogb-input-lg:focus { border-color: var(--ogb-teal); outline: none; box-shadow: 0 0 0 4px rgba(20,184,166,.22); }
.ogb-clearx { position: absolute; right: 8px; top: 50%; transform: translateY(-50%); width: 34px; height: 34px; border-radius: 8px; border: 0; background: transparent; color: var(--ogb-muted); cursor: pointer; display: grid; place-items: center; }
.ogb-clearx:hover { background: var(--ogb-surface-2); color: var(--ogb-ink); }
.ogb-clearx svg { position: static; transform: none; width: 18px; height: 18px; }
.ogb-live-hint { margin-top: 10px; display: flex; flex-wrap: wrap; gap: 8px; align-items: center; min-height: 28px; font-size: .9rem; color: var(--ogb-muted); }
.ogb-helper { font-size: .9rem; color: var(--ogb-muted); margin-top: 6px; }
.ogb-pills { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 14px; }
.ogb-pill { border: 1px solid var(--ogb-line); background: var(--ogb-surface-2); color: var(--ogb-ink-2); border-radius: 999px; padding: 6px 13px; font-size: .88rem; cursor: pointer; font-family: var(--ogb-mono); letter-spacing: -.01em; min-height: 34px; }
.ogb-pill:hover { border-color: var(--ogb-teal); color: var(--ogb-ink); background: var(--ogb-surface); }
.ogb-phi { display: flex; gap: 8px; align-items: flex-start; margin-top: 14px; padding-top: 12px; border-top: 1px dashed var(--ogb-line); font-size: .85rem; color: var(--ogb-ink-2); }
.ogb-phi svg { width: 16px; height: 16px; flex: none; margin-top: 2px; color: var(--ogb-warn); }

/* ── Buttons ────────────────────────────────────────────── */
.ogb-btn { display: inline-flex; align-items: center; justify-content: center; gap: 7px; min-height: 40px; padding: 0 14px; border-radius: 9px; border: 1px solid var(--ogb-line-strong); background: var(--ogb-surface); color: var(--ogb-ink); cursor: pointer; font-size: .92rem; font-weight: 550; text-decoration: none; white-space: nowrap; }
.ogb-btn:hover { background: var(--ogb-surface-2); }
.ogb-btn:disabled { opacity: .5; cursor: not-allowed; }
.ogb-btn svg { width: 17px; height: 17px; flex: none; }
.ogb-btn-primary { background: var(--ogb-navy); border-color: var(--ogb-navy); color: #fff; }
.ogb-btn-primary:hover { background: var(--ogb-navy-2); }
.oncogx-biology[data-theme="dark"] .ogb-btn-primary { background: var(--ogb-teal); border-color: var(--ogb-teal); color: #04201C; }
@media (prefers-color-scheme: dark) { .oncogx-biology[data-theme="auto"] .ogb-btn-primary { background: var(--ogb-teal); border-color: var(--ogb-teal); color: #04201C; } }
.ogb-btn-xl { height: 56px; padding: 0 26px; font-size: 1.05rem; border-radius: 12px; }
.ogb-btn-ghost { background: transparent; border-color: transparent; color: var(--ogb-teal-ink); }
.ogb-btn-ghost:hover { background: var(--ogb-surface-2); }
.ogb-btn-danger { color: var(--ogb-danger); }
.ogb-btn-sm { min-height: 32px; padding: 0 10px; font-size: .85rem; border-radius: 7px; }
.ogb-linkbtn { background: none; border: 0; padding: 0; color: var(--ogb-teal-ink); cursor: pointer; text-decoration: underline; text-underline-offset: 2px; font-size: inherit; }

/* ── Badges ─────────────────────────────────────────────── */
.ogb-badge { display: inline-flex; align-items: center; gap: 5px; padding: 2px 9px; border-radius: 999px; font-size: .78rem; font-weight: 600; line-height: 1.6; border: 1px solid transparent; white-space: nowrap; }
.ogb-badge svg { width: 12px; height: 12px; }
.ogb-b-gene { color: var(--ogb-gene); background: var(--ogb-gene-bg); }
.ogb-b-variant, .ogb-b-rsid, .ogb-b-hgvs { color: var(--ogb-variant); background: var(--ogb-variant-bg); }
.ogb-b-protein { color: var(--ogb-protein); background: var(--ogb-protein-bg); }
.ogb-b-pathway { color: var(--ogb-pathway); background: var(--ogb-pathway-bg); }
.ogb-b-interact { color: var(--ogb-interact); background: var(--ogb-interact-bg); }
.ogb-b-neutral, .ogb-b-concept, .ogb-b-unclassified { color: var(--ogb-ink-2); background: var(--ogb-surface-2); }
.ogb-b-ok { color: var(--ogb-ok); background: var(--ogb-ok-bg); }
.ogb-b-warn { color: var(--ogb-warn); background: var(--ogb-warn-bg); }
.ogb-b-danger { color: var(--ogb-danger); background: var(--ogb-danger-bg); }
.ogb-b-outline { border-color: var(--ogb-line-strong); color: var(--ogb-ink-2); background: transparent; }
.ogb-impact-HIGH { color: var(--ogb-danger); background: var(--ogb-danger-bg); }
.ogb-impact-MODERATE { color: var(--ogb-warn); background: var(--ogb-warn-bg); }
.ogb-impact-LOW { color: var(--ogb-variant); background: var(--ogb-variant-bg); }
.ogb-impact-MODIFIER { color: var(--ogb-ink-2); background: var(--ogb-surface-2); }

/* ── Detector + status ─────────────────────────────────── */
.ogb-detector { margin-top: 18px; display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 14px 20px; align-items: start; }
.ogb-detected { display: flex; flex-wrap: wrap; gap: 8px 12px; align-items: center; }
.ogb-detected-term { font-family: var(--ogb-mono); font-size: 1.05rem; font-weight: 600; overflow-wrap: anywhere; }
.ogb-normalized { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 8px; }
.ogb-token { font-family: var(--ogb-mono); font-size: .82rem; background: var(--ogb-surface-2); border: 1px solid var(--ogb-line); border-radius: 6px; padding: 2px 8px; overflow-wrap: anywhere; }
.ogb-note { font-size: .88rem; color: var(--ogb-ink-2); margin-top: 8px; }
.ogb-candidates { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 10px; align-items: center; }
.ogb-statusbar { margin-top: 18px; background: var(--ogb-surface); border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius-lg); padding: 12px 14px; display: flex; flex-wrap: wrap; gap: 10px 16px; align-items: center; justify-content: space-between; }
.ogb-sources { display: flex; flex-wrap: wrap; gap: 6px; }
.ogb-src { display: inline-flex; align-items: center; gap: 6px; font-size: .8rem; padding: 3px 9px 3px 7px; border-radius: 999px; border: 1px solid var(--ogb-line); background: var(--ogb-surface); color: var(--ogb-ink-2); white-space: nowrap; }
.ogb-dot { width: 8px; height: 8px; border-radius: 50%; background: var(--ogb-line-strong); flex: none; }
.ogb-src[data-status="loading"] .ogb-dot { background: var(--ogb-teal); animation: ogb-pulse 1s ease-in-out infinite; }
.ogb-src[data-status="ok"] .ogb-dot { background: var(--ogb-ok); }
.ogb-src[data-status="empty"] .ogb-dot { background: var(--ogb-muted); }
.ogb-src[data-status="error"] .ogb-dot, .ogb-src[data-status="blocked"] .ogb-dot { background: var(--ogb-danger); }
.ogb-src[data-status="ratelimited"] .ogb-dot { background: var(--ogb-warn); }
.ogb-src[data-status="linkout"] .ogb-dot { background: transparent; border: 1.5px solid var(--ogb-muted); }
@keyframes ogb-pulse { 50% { opacity: .35; } }
.ogb-stats { font-size: .84rem; color: var(--ogb-muted); display: flex; gap: 12px; flex-wrap: wrap; }
.ogb-stats b { color: var(--ogb-ink); font-weight: 650; }
.ogb-actions { display: flex; flex-wrap: wrap; gap: 6px; }
.ogb-alert { margin-top: 12px; padding: 10px 14px; border-radius: var(--ogb-radius); font-size: .9rem; display: flex; gap: 10px; align-items: flex-start; border: 1px solid transparent; }
.ogb-alert svg { width: 18px; height: 18px; flex: none; margin-top: 1px; }
.ogb-alert-warn { background: var(--ogb-warn-bg); color: var(--ogb-ink); border-color: color-mix(in srgb, var(--ogb-warn) 30%, transparent); }
.ogb-alert-warn svg { color: var(--ogb-warn); }
.ogb-alert-danger { background: var(--ogb-danger-bg); color: var(--ogb-ink); }
.ogb-alert-danger svg { color: var(--ogb-danger); }
.ogb-alert-info { background: var(--ogb-surface-2); color: var(--ogb-ink); }
.ogb-alert-info svg { color: var(--ogb-teal-ink); }

/* ── Tabs ───────────────────────────────────────────────── */
.ogb-workspace { margin-top: 22px; }
.ogb-tablist { display: flex; gap: 2px; overflow-x: auto; scrollbar-width: thin; border-bottom: 1px solid var(--ogb-line); scroll-snap-type: x proximity; -webkit-overflow-scrolling: touch; }
.ogb-tab { flex: none; scroll-snap-align: start; display: inline-flex; align-items: center; gap: 8px; padding: 12px 14px 11px; border: 0; border-bottom: 3px solid transparent; background: transparent; color: var(--ogb-muted); font-weight: 600; font-size: .93rem; cursor: pointer; white-space: nowrap; min-height: 46px; }
.ogb-tab:hover { color: var(--ogb-ink); }
.ogb-tab[aria-selected="true"] { color: var(--ogb-ink); border-bottom-color: var(--ogb-teal); }
.ogb-tab svg { width: 16px; height: 16px; }
.ogb-tab .ogb-count { font-size: .74rem; background: var(--ogb-surface-2); border-radius: 999px; padding: 0 7px; color: var(--ogb-ink-2); font-weight: 600; }
.ogb-panel { padding: 22px 0 8px; }
.ogb-panel:focus-visible { outline-offset: 6px; }
.ogb-panelhead { display: flex; justify-content: space-between; gap: 12px; flex-wrap: wrap; align-items: flex-end; margin-bottom: 16px; }
.ogb-panelhead h2 { font-size: 1.35rem; font-weight: 720; }
.ogb-panelhead p { color: var(--ogb-muted); font-size: .92rem; margin: 4px 0 0; max-width: 70ch; }
.ogb-poweredby { font-size: .8rem; color: var(--ogb-muted); }

/* ── Cards, grids ───────────────────────────────────────── */
.ogb-card { background: var(--ogb-surface); border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius-lg); padding: clamp(14px, 2vw, 20px); min-width: 0; }
.ogb-card + .ogb-card { margin-top: 14px; }
.ogb-card h3 { font-size: 1.02rem; font-weight: 700; margin-bottom: 10px; display: flex; align-items: center; gap: 8px; flex-wrap: wrap; }
.ogb-card h3 svg { width: 18px; height: 18px; }
.ogb-grid { display: grid; gap: 14px; }
.ogb-grid > .ogb-card + .ogb-card { margin-top: 0; }
.ogb-grid-2 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
.ogb-grid-3 { grid-template-columns: repeat(3, minmax(0, 1fr)); }
.ogb-grid-main { grid-template-columns: minmax(0, 1.7fr) minmax(0, 1fr); }
.ogb-kv { display: grid; grid-template-columns: minmax(120px, max-content) minmax(0, 1fr); gap: 7px 18px; margin: 0; font-size: .93rem; }
.ogb-kv dt { color: var(--ogb-muted); }
.ogb-kv dd { margin: 0; overflow-wrap: anywhere; min-width: 0; }
.ogb-kpis { display: grid; grid-template-columns: repeat(auto-fill, minmax(150px, 1fr)); gap: 10px; }
.ogb-kpi { background: var(--ogb-surface); border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius); padding: 12px 14px; }
.ogb-kpi-n { font-size: 1.45rem; font-weight: 750; font-variant-numeric: tabular-nums; line-height: 1.15; }
.ogb-kpi-l { font-size: .82rem; color: var(--ogb-muted); margin-top: 2px; }
.ogb-kpi[data-kind="gene"] { border-left: 4px solid var(--ogb-gene); }
.ogb-kpi[data-kind="variant"] { border-left: 4px solid var(--ogb-variant); }
.ogb-kpi[data-kind="protein"] { border-left: 4px solid var(--ogb-protein); }
.ogb-kpi[data-kind="pathway"] { border-left: 4px solid var(--ogb-pathway); }
.ogb-kpi[data-kind="interact"] { border-left: 4px solid var(--ogb-interact); }
.ogb-kpi[data-kind="lit"] { border-left: 4px solid var(--ogb-teal); }

/* The notation ladder: how a query resolves across representations. */
.ogb-ladder { display: grid; grid-template-columns: repeat(auto-fit, minmax(170px, 1fr)); gap: 0; border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius-lg); overflow: hidden; background: var(--ogb-surface); }
.ogb-rung { padding: 14px 16px; border-right: 1px solid var(--ogb-line); position: relative; min-width: 0; }
.ogb-rung:last-child { border-right: 0; }
.ogb-rung-k { font-size: .78rem; color: var(--ogb-muted); display: flex; align-items: center; gap: 6px; }
.ogb-rung-k::before { content: ""; width: 8px; height: 8px; border-radius: 2px; background: var(--ogb-rung, var(--ogb-line-strong)); }
.ogb-rung-v { margin-top: 5px; font-family: var(--ogb-mono); font-size: .95rem; font-weight: 600; overflow-wrap: anywhere; }
.ogb-rung-v.ogb-empty { color: var(--ogb-muted); font-weight: 400; font-family: var(--ogb-font); font-size: .88rem; }
.ogb-rung-s { font-size: .76rem; color: var(--ogb-muted); margin-top: 3px; }

/* bars */
.ogb-bars { display: grid; gap: 8px; }
.ogb-bar { display: grid; grid-template-columns: minmax(90px, 38%) minmax(0, 1fr) 42px; gap: 10px; align-items: center; font-size: .86rem; }
.ogb-bar-l { overflow: hidden; text-overflow: ellipsis; white-space: nowrap; color: var(--ogb-ink-2); }
.ogb-bar-t { height: 10px; background: var(--ogb-surface-2); border-radius: 999px; overflow: hidden; }
.ogb-bar-f { height: 100%; background: var(--ogb-teal); border-radius: 999px; min-width: 2px; }
.ogb-bar-n { text-align: right; font-variant-numeric: tabular-nums; color: var(--ogb-muted); }

/* lists, chips */
.ogb-chips { display: flex; flex-wrap: wrap; gap: 6px; }
.ogb-chip { font-size: .82rem; padding: 3px 9px; border-radius: 6px; background: var(--ogb-surface-2); border: 1px solid var(--ogb-line); color: var(--ogb-ink-2); overflow-wrap: anywhere; max-width: 100%; }
.ogb-linkrow { display: flex; flex-wrap: wrap; gap: 8px 14px; font-size: .9rem; }
.ogb-linkrow a { display: inline-flex; align-items: center; gap: 5px; }
.ogb-linkrow svg { width: 13px; height: 13px; }
.ogb-muted { color: var(--ogb-muted); }
.ogb-small { font-size: .86rem; }
.ogb-disclaimer { font-size: .86rem; color: var(--ogb-ink-2); background: var(--ogb-surface-2); border-left: 3px solid var(--ogb-warn); padding: 8px 12px; border-radius: 0 8px 8px 0; margin-bottom: 14px; }
.ogb-clamp { display: -webkit-box; -webkit-line-clamp: 4; -webkit-box-orient: vertical; overflow: hidden; }
.ogb-clamp.ogb-open { display: block; -webkit-line-clamp: unset; }
.ogb-ul { margin: 0; padding-left: 1.1em; }
.ogb-ul li { margin: .2em 0; }

/* empty / error */
.ogb-empty-state { text-align: left; padding: 22px; border: 1px dashed var(--ogb-line-strong); border-radius: var(--ogb-radius-lg); background: var(--ogb-surface); color: var(--ogb-ink-2); }
.ogb-empty-state h3 { font-size: 1.02rem; margin-bottom: 6px; color: var(--ogb-ink); }
.ogb-linkout { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 12px; }

/* welcome */
.ogb-welcome { margin-top: 26px; display: grid; grid-template-columns: minmax(0, 1.25fr) minmax(0, 1fr); gap: 16px; }
.ogb-welcome h2 { font-size: 1.25rem; margin-bottom: 10px; }
.ogb-questions { list-style: none; margin: 0; padding: 0; display: grid; gap: 6px; }
.ogb-questions li { display: flex; gap: 10px; align-items: baseline; padding: 7px 0; border-bottom: 1px solid var(--ogb-line); font-size: .95rem; }
.ogb-questions li:last-child { border-bottom: 0; }
.ogb-questions .ogb-badge { flex: none; }

/* skeleton */
.ogb-skel { display: grid; gap: 10px; }
.ogb-skel i { display: block; height: 14px; border-radius: 6px; background: linear-gradient(90deg, var(--ogb-surface-2), var(--ogb-surface-3), var(--ogb-surface-2)); background-size: 200% 100%; animation: ogb-shimmer 1.3s linear infinite; }
.ogb-skel i:nth-child(2n) { width: 82%; } .ogb-skel i:nth-child(3n) { width: 64%; }
@keyframes ogb-shimmer { to { background-position: -200% 0; } }

/* tables */
.ogb-tablewrap { overflow-x: auto; border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius); background: var(--ogb-surface); }
.ogb-table { width: 100%; border-collapse: collapse; font-size: .88rem; }
.ogb-table th, .ogb-table td { text-align: left; padding: 9px 12px; border-bottom: 1px solid var(--ogb-line); vertical-align: top; }
.ogb-table th { background: var(--ogb-surface-2); font-weight: 650; color: var(--ogb-ink-2); white-space: nowrap; position: sticky; top: 0; }
.ogb-table tr:last-child td { border-bottom: 0; }
.ogb-table td { overflow-wrap: anywhere; min-width: 70px; }
.ogb-table tbody tr[data-clickable]:hover { background: var(--ogb-surface-2); cursor: pointer; }
.ogb-sortbtn { background: none; border: 0; padding: 0; font-weight: 650; color: inherit; cursor: pointer; display: inline-flex; align-items: center; gap: 4px; }
.ogb-sortbtn svg { width: 12px; height: 12px; opacity: .6; }
.ogb-tabletools { display: flex; flex-wrap: wrap; gap: 8px; align-items: center; justify-content: space-between; margin: 0 0 10px; }
.ogb-pager { display: flex; align-items: center; gap: 8px; justify-content: flex-end; margin-top: 10px; font-size: .86rem; color: var(--ogb-muted); flex-wrap: wrap; }
.ogb-seg { display: inline-flex; border: 1px solid var(--ogb-line-strong); border-radius: 8px; overflow: hidden; }
.ogb-seg button { border: 0; background: var(--ogb-surface); padding: 6px 12px; cursor: pointer; font-size: .85rem; min-height: 32px; }
.ogb-seg button[aria-pressed="true"] { background: var(--ogb-navy); color: #fff; }
.ogb-scorebar { display: inline-block; width: 70px; height: 7px; background: var(--ogb-surface-2); border-radius: 999px; vertical-align: middle; margin-right: 8px; overflow: hidden; }
.ogb-scorebar i { display: block; height: 100%; background: var(--ogb-interact); }

/* form controls */
.ogb-field { display: grid; gap: 5px; min-width: 0; }
.ogb-field label, .ogb-field .ogb-flabel { font-size: .84rem; font-weight: 600; color: var(--ogb-ink-2); }
.ogb-input, .ogb-select { width: 100%; min-height: 40px; padding: 7px 11px; border: 1px solid var(--ogb-line-strong); border-radius: 8px; background: var(--ogb-surface); font-size: .93rem; }
.ogb-input:focus, .ogb-select:focus { outline: none; border-color: var(--ogb-teal); box-shadow: 0 0 0 3px rgba(20,184,166,.2); }
.ogb-check { display: inline-flex; gap: 8px; align-items: center; font-size: .9rem; cursor: pointer; min-height: 32px; }
.ogb-check input { width: 18px; height: 18px; accent-color: var(--ogb-teal-ink); }
.ogb-formgrid { display: grid; grid-template-columns: repeat(auto-fill, minmax(190px, 1fr)); gap: 12px; }
.ogb-help { font-size: .8rem; color: var(--ogb-muted); }
.ogb-pre { background: var(--ogb-surface-2); border: 1px solid var(--ogb-line); border-radius: 8px; padding: 12px; font-family: var(--ogb-mono); font-size: .8rem; white-space: pre-wrap; overflow-wrap: anywhere; max-height: 460px; overflow: auto; margin: 0; }
.ogb-details { border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius); background: var(--ogb-surface); }
.ogb-details > summary { cursor: pointer; padding: 10px 14px; font-weight: 600; font-size: .92rem; list-style-position: inside; }
.ogb-details[open] > summary { border-bottom: 1px solid var(--ogb-line); }
.ogb-details > div { padding: 12px 14px; }

/* literature */
.ogb-litlist { display: grid; gap: 10px; }
.ogb-lit { background: var(--ogb-surface); border: 1px solid var(--ogb-line); border-radius: var(--ogb-radius); padding: 14px 16px; }
.ogb-lit h4 { font-size: .99rem; font-weight: 650; line-height: 1.35; }
.ogb-lit h4 button { all: unset; cursor: pointer; }
.ogb-lit h4 button:hover { text-decoration: underline; }
.ogb-lit h4 button:focus-visible { outline: 3px solid var(--ogb-focus); outline-offset: 2px; border-radius: 3px; }
.ogb-litmeta { font-size: .83rem; color: var(--ogb-muted); margin-top: 4px; display: flex; flex-wrap: wrap; gap: 4px 12px; }
.ogb-litabs { font-size: .88rem; color: var(--ogb-ink-2); margin-top: 8px; }
.ogb-filters { display: grid; grid-template-columns: repeat(auto-fill, minmax(150px, 1fr)); gap: 10px; align-items: end; margin-bottom: 14px; }

/* domain map */
.ogb-domainmap { width: 100%; height: auto; display: block; margin: 4px 0 8px; }
.ogb-legend { display: flex; flex-wrap: wrap; gap: 6px 14px; font-size: .8rem; color: var(--ogb-muted); }
.ogb-legend span { display: inline-flex; align-items: center; gap: 6px; }
.ogb-legend i { width: 12px; height: 8px; border-radius: 2px; display: inline-block; }

/* crosslinks */
.ogb-xl { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 14px; }
.ogb-xl .ogb-card { display: flex; flex-direction: column; gap: 10px; }
.ogb-xl .ogb-card .ogb-actions { margin-top: auto; }

/* drawer + modal */
.ogb-backdrop { position: fixed; inset: 0; background: rgba(6,18,34,.5); z-index: 2147483000; opacity: 0; transition: opacity .18s ease; }
.ogb-backdrop.ogb-show { opacity: 1; }
.ogb-drawer { position: fixed; top: 0; right: 0; bottom: 0; width: min(520px, 100vw); background: var(--ogb-surface); color: var(--ogb-ink); z-index: 2147483001; box-shadow: -8px 0 30px rgba(0,0,0,.18); display: flex; flex-direction: column; transform: translateX(24px); opacity: 0; transition: transform .2s ease, opacity .2s ease; padding-top: env(safe-area-inset-top, 0px); }
.ogb-drawer.ogb-show { transform: none; opacity: 1; }
.ogb-drawer-h { display: flex; align-items: flex-start; justify-content: space-between; gap: 12px; padding: 16px 18px; border-bottom: 1px solid var(--ogb-line); }
.ogb-drawer-h h2 { font-size: 1.08rem; overflow-wrap: anywhere; }
.ogb-drawer-b { padding: 16px 18px 28px; overflow-y: auto; flex: 1; overscroll-behavior: contain; }
.ogb-iconbtn { width: 40px; height: 40px; border-radius: 9px; border: 1px solid var(--ogb-line); background: var(--ogb-surface); cursor: pointer; display: grid; place-items: center; flex: none; color: var(--ogb-ink); }
.ogb-iconbtn:hover { background: var(--ogb-surface-2); }
.ogb-iconbtn svg { width: 18px; height: 18px; }
.ogb-modal { position: fixed; z-index: 2147483001; left: 50%; top: 50%; transform: translate(-50%, -48%); width: min(640px, calc(100vw - 24px)); max-height: calc(100vh - 40px); background: var(--ogb-surface); color: var(--ogb-ink); border-radius: var(--ogb-radius-lg); box-shadow: 0 20px 60px rgba(0,0,0,.3); display: flex; flex-direction: column; opacity: 0; transition: opacity .18s ease, transform .18s ease; }
.ogb-modal.ogb-show { opacity: 1; transform: translate(-50%, -50%); }
.ogb-modal .ogb-drawer-b { max-height: none; }
.ogb-modal-f { display: flex; justify-content: flex-end; gap: 8px; padding: 12px 18px; border-top: 1px solid var(--ogb-line); flex-wrap: wrap; }
@media (max-width: 720px) {
  .ogb-drawer { top: auto; left: 0; width: 100vw; max-height: 88vh; border-radius: 16px 16px 0 0; transform: translateY(24px); padding-bottom: env(safe-area-inset-bottom, 0px); }
  .ogb-modal { top: auto; bottom: 0; left: 0; width: 100vw; transform: translateY(12px); border-radius: 16px 16px 0 0; max-height: 92vh; }
  .ogb-modal.ogb-show { transform: none; }
}

/* footer */
.ogb-footer { margin-top: 36px; border-top: 1px solid var(--ogb-line); padding: 22px 0 30px; font-size: .84rem; color: var(--ogb-muted); }
.ogb-footer p { max-width: 90ch; }
.ogb-footer-top { display: flex; justify-content: space-between; gap: 12px; flex-wrap: wrap; align-items: center; margin-bottom: 10px; }

/* toast */
.ogb-toasts { position: fixed; left: 50%; bottom: calc(18px + env(safe-area-inset-bottom, 0px)); transform: translateX(-50%); z-index: 2147483002; display: grid; gap: 8px; pointer-events: none; width: min(460px, calc(100vw - 24px)); }
.ogb-toast { background: var(--ogb-navy); color: #fff; padding: 10px 14px; border-radius: 10px; font-size: .9rem; box-shadow: 0 8px 24px rgba(0,0,0,.25); }

/* responsive */
@media (max-width: 1040px) {
  .ogb-grid-main, .ogb-grid-3 { grid-template-columns: minmax(0, 1fr); }
  .ogb-welcome { grid-template-columns: minmax(0, 1fr); }
}
@media (max-width: 760px) {
  .ogb-grid-2, .ogb-xl { grid-template-columns: minmax(0, 1fr); }
  .ogb-detector { grid-template-columns: minmax(0, 1fr); }
  .ogb-searchrow { flex-direction: column; }
  .ogb-btn-xl { width: 100%; }
  .ogb-kv { grid-template-columns: minmax(0, 1fr); gap: 2px 0; }
  .ogb-kv dd { margin-bottom: 8px; }
  .ogb-rung { border-right: 0; border-bottom: 1px solid var(--ogb-line); }
  .ogb-rung:last-child { border-bottom: 0; }
  .ogb-header { padding-bottom: 70px; }
  .ogb-statusbar { align-items: flex-start; }
}
@media (prefers-reduced-motion: reduce) {
  .oncogx-biology *, .oncogx-biology *::before, .oncogx-biology *::after { animation: none !important; transition: none !important; }
}
@media print {
  .oncogx-biology { background: #fff; color: #000; }
  .ogb-header { background: #fff; color: #000; padding: 0 0 10px; }
  .ogb-header::after, .ogb-searchcard, .ogb-statusbar, .ogb-tablist, .ogb-actions, .ogb-toasts, .ogb-backdrop, .ogb-drawer, .ogb-modal, .ogb-pager, .ogb-tabletools, .ogb-filters, .ogb-hbadge, .ogb-skip { display: none !important; }
  .ogb-title h1, .ogb-title p { color: #000; }
  .ogb-card, .ogb-lit, .ogb-kpi { break-inside: avoid; box-shadow: none; }
  .ogb-panel[hidden] { display: none !important; }
}

/* ======================================================================
   OncoGx site theme overrides
   Map the interpreter's tokens onto the site's design tokens so it matches
   the rest of OncoGx (and the other explorers) in light and dark mode.
   data-theme follows the site toggle (see pages/biology-interpreter.html).
   ====================================================================== */
.oncogx-biology,
.oncogx-biology[data-theme] {
  --ogb-navy: #1C1A33;
  --ogb-navy-2: #26234A;
  --ogb-teal: #4CC3C8;
  --ogb-teal-ink: var(--primary);
  --ogb-bg: var(--bg);
  --ogb-surface: var(--surface);
  --ogb-surface-2: var(--surface-2);
  --ogb-line: var(--line);
  --ogb-ink: var(--ink);
  --ogb-ink-2: var(--ink-2);
  --ogb-muted: var(--muted);
  --ogb-focus: var(--primary);
  --ogb-radius-lg: var(--r-md);
  --ogb-font: var(--sans);
  --ogb-maxw: var(--maxw);
  --ogb-sticky-top: var(--header-h);
  position: relative;
}
.oncogx-biology .ogb-wrap { padding-inline: var(--gutter); }
.oncogx-biology .ogb-header {
  background: radial-gradient(900px 380px at 88% -10%, rgba(107,91,196,.45), transparent 60%),
              radial-gradient(700px 300px at 0% 120%, rgba(76,195,200,.28), transparent 60%),
              linear-gradient(135deg, #1C1A33 0%, #26234A 60%, #2F2A63 100%);
}
.oncogx-biology .ogb-header-top { justify-content: flex-start; }
.oncogx-biology h1,
.oncogx-biology .ogb-panelhead h2,
.oncogx-biology .ogb-drawer-h h2,
.oncogx-biology h2.ogb-h2 { font-family: var(--serif); }
.oncogx-biology .ogb-title h1 { font-weight: 600; letter-spacing: -.01em; }
/* skip link: hidden until focused */
.oncogx-biology .ogb-skip:not(:focus) { position: absolute; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0; }

/* ---------- mobile friendliness (site embed) ---------- */
@media (max-width: 760px) {
  .oncogx-biology input:not([type=checkbox]):not([type=radio]),
  .oncogx-biology select,
  .oncogx-biology textarea { font-size: 16px; }
  .oncogx-biology .ogb-linkbtn,
  .oncogx-biology .ogb-linkrow a,
  .oncogx-biology .ogb-footer a { display: inline-block; padding-block: 6px; }
  .oncogx-biology [role=tab] { min-height: 44px; }
  .oncogx-biology .ogb-hbadge { min-height: 40px; }
}